SATB2 in Combination With Cytokeratin 20 Identifies Over 95
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Forms. If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen. Special AT-rich sequence binding protein 2 (SATB2) is a 733–amino acid human DNA-binding protein involved in transcriptional regulation and chromatin remodeling, and its expression is restricted to glandular cells lining the lower GI tract. 22 A recent study demonstrated that SATB2 is a sensitive and highly specific marker for colorectal carcinoma (CRC) with distinct positivity in 85% of all CRCs, and SATB2 … IRES cre is expressed from the mouse Satb2 (special AT-rich sequence binding protein 2) promoter in this targeted mutant strain. When crossed with mice carrying loxP-flanked sequences of interest, floxed regions are excised in Satb2-expressing cells of the parabrachial nucleus (PBN).
Using comparative genomics, Rainger et al. (2014) identified 3 different functional enhancing cis-regulatory elements (CREs) in the gene desert between the PLCL1 and SATB2 genes, 3-prime to SATB2. 2020-06-27 · SATB2 stains osteoblasts and can be helpful. Conventional Osteosarcoma Low-grade malignant. Arises in the intramedullary cavity, most often in the View mouse Satb2 Chr1:56793981-56978650 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression Results: SATB2 single stain showed a good sensitivity of 83% and the highest specificity of 78% for AMNs over OMNs among all four stains. DS with SATB2 and villin showed an identical sensitivity beta-catenin overexpression, microsatellite stability and SATB2 expression.
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Complete information for SATB2 gene (Protein Coding), SATB Homeobox 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium Triple Stain PSA PSAP/HPAPMLH1 PSMA PTH RCC1 S100 ESCC (Esophageal) S100p SALL4 SATB2(PASD+PAS) Serotonin. Reticulin SF1 SMA SMMHC Smoothelin Somatostatin SSTR2 (Somatostatin Receptor, Type 2) SOX2 SOX10 SOX11 STAT6 Surfactant TCL1 TCR BetaF1 TCR Delta Thrombomodulin (TM) Thyroglobulin (TGB) TIA1 Test Code SATB2 SATB2 Immunostain, Technical Component Only Advisory Information This test includes only technical performance of the stain (no pathologist interpretation is performed). Immunohistochemistry and special stains play an increasingly important role in gastrointestinal pathology practice.
Prognostisk signifikans av SATB1 och SATB2 uttryck i - MUEP
Recently, SATB2 has been shown to be highly expressed in the epithelium of the lower gastrointestinal tract, with a relatively narrow expression profile in malignancies, including colorectal/appendiceal adenocarcinomas, tumors of osteoblastic differentiation, and renal/urothelial carcinomas. SAT B2 A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides Block and slide identifiers should be clearly written and match exactly with the Value of SATB2 immunostaining in the distinction between small intestinal and colorectal adenocarcinomas. SATB2 is not entirely CRC-specific and is expressed in a subset of SIAs. Unlike CRC, however, SIA infrequently shows a strong and diffuse staining pattern, which still makes SATB2 a useful immunomarker to distinguish SIA from CRC. SATB2 is not entirely CRC-specific and is expressed in a subset of SIAs. SATB2 dual stain shows the greatest potential clinical utility in identifying CRC and is superior to CDX2 dual stain.
Reticulin SF1 SMA SMMHC Smoothelin Somatostatin SSTR2 (Somatostatin Receptor, Type 2) SOX2 SOX10 SOX11 STAT6 Surfactant TCL1 TCR BetaF1 TCR Delta Thrombomodulin (TM) Thyroglobulin (TGB) TIA1
2020-06-27
SATB2 also regulates skeletal development, osteoblast differentiation, and modulates immunoglobulin expression. In normal tissues, strong nuclear SATB2 expression is observed in essentially all glandular cells lining the lower gastrointestinal tract, including the appendix, colon, and rectum. SATB2 is also
Methods: Immunohistochemical stains for SATB2 and CDX2 were performed in 49 appendiceal adenocarcinomas (23 conventional, 26 adenocarcinoma ex goblet cell …
Dual Stain With SATB2 and CK20/Villin Is Useful to Distinguish Colorectal Carcinomas From Other Tumors. Zaibo Li et al.
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Creytens, David MD, PhD *,† Author Information * Test ID SATB2 SATB2 Immunostain, Technical Component Only Advisory Information This test includes only technical performance of the stain (no pathologist interpretation is performed).
A nuclear localizing signal (NLS) directs expression of cre to the nucleus. Three quarters of gastric primaries stain for CDX2 and only rare examples stain for SATB2.
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Special AT-rich sequence binding protein 2 (SATB2) has been shown to be highly selectively expressed in the lower gastrointestinal tract, including the appendix. Methods: We investigated the utility of a dual stain (DS) with SATB2 or caudal type homeobox 2 (CDX2) and cytokeratin 20 (CK20) or villin in distinguishing AMNs from OMNs.